Fig. 5: The effects of I-PpoI-induced DSBs on changes in DNA methylation in peripheral blood cells in the I-PpoI mice. | Nature Communications

Fig. 5: The effects of I-PpoI-induced DSBs on changes in DNA methylation in peripheral blood cells in the I-PpoI mice.

From: DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages

Fig. 5

A Significant signaling pathways of hypermethylated DMRs specifically in blood cells of the I-PpoI mice (Tg) compared to those in blood cells of WT mice. B Significant signaling pathways of hypomethylated DMRs specifically in blood cells of the I-PpoI mice compared to those in blood cells of WT mice. C The top 5 enriched motifs in hypomethylated DMRs, including promoter regions and CpG islands, of blood cells in the I-PpoI mice according to regulatory sequence analysis tools. For each motif, the corresponding Bonferroni-adjusted p value (E value) and the number of input sequences containing the specific motif (n in parenthesis) are listed on top of the motif logo. The known JASPAR transcription factors are listed below the corresponding logo. D Relative methylation rate of Gasdermin D (GSDMD) in blood cells of the I-PpoI mice compared to those in blood cells of WT mice. **p < 0.01 vs. the control. Source data are provided as a Source Data file.

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