Fig. 4: In Vivo Electrophysiological Recording of Extracellular Action Potentials and Local Field Potentials Using FPE-PEDOT. | Nature Communications

Fig. 4: In Vivo Electrophysiological Recording of Extracellular Action Potentials and Local Field Potentials Using FPE-PEDOT.

From: Transparent, metal-free PEDOT:PSS neural interfaces for simultaneous recording of low-noise electrophysiology and artifact-free two-photon imaging

Fig. 4: In Vivo Electrophysiological Recording of Extracellular Action Potentials and Local Field Potentials Using FPE-PEDOT.

a Protocol for in-vivo electrophysiological signal measurement experiments. Fig. 4a mouse and syringe created with BioRender.com. Created in BioRender92. b Photograph of the FPE-PEDOT electrodes implanted in the somatosensory cortex and localized negative peaks in extracellular action potentials are shown across FPE-PEDOT electrodes under normal conditions. Flat black lines indicate channels with no detected spikes. Scale bar of the photograph, 2 mm. c High-pass filtered recordings comparing spike detection performance of FPE-PEDOT and ITO electrodes after pilocarpine injection. d Electrophysiological signals obtained from FPE-PEDOT, Pt-black, and ITO electrodes. The root mean square (RMS) noises represents the values of the signal that have been high-pass filtered. e Inter spike intervals, sorted spike waveforms, and signal-to-noise ratio (SNR) for FPE-PEDOT, graphene, and Pt-black electrodes. f Spectrogram of evoked local field potential power spectral density recorded by the FPE-PEDOT in a normal mouse. g Spectrogram showing evoked LFP signals following pilocarpine-induced seizures.

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