Fig. 5: TCR usages and overlapping TCR clonotypes of circulating and hepatic MAIT cells. | Nature Communications

Fig. 5: TCR usages and overlapping TCR clonotypes of circulating and hepatic MAIT cells.

From: Liver transplant-facilitated CD161+Vα7.2+ MAIT cell recovery demonstrates clinical benefits in hepatic failure patients

Fig. 5: TCR usages and overlapping TCR clonotypes of circulating and hepatic MAIT cells.The alternative text for this image may have been generated using AI.

TCR usages and clonotypes of MAIT cells were analyzed among immune active (IA, n = 5), immune tolerance (IT, n = 6), and healthy control (HC, n = 6) groups sourced from dataset GSE182159. A Chord diagrams depict TRAJ and TRBV usages of MAIT cells defined by TRAV1-2+SLC4A10+ in the indicated groups. B The bar graph, featuring different colors, depicts the ratios of clones with varying frequencies of identical CDR3α or CDR3β sequences. C The bar graphs depict ratios of clones with varying frequencies of identical paired CDR3α and CDR3β sequences in both blood and liver of the indicated groups. D TCR diversity assessed by the Shannon equitability index in IA (n = 5), HC (n = 6), and IT (n = 6) groups. Data are presented as mean ± SEM. n-values represent biological replicates. Statistical significance was assessed by a one-way ANOVA test followed by Fisher’s LSD test. Source data are provided as a Source Data file. E The chord diagrams show the frequencies of the liver-blood sharing TCR clonotypes among MAIT cells with clonal frequency over 5 in the indicated groups with patient ID, Clone name, and clone frequency (ID:Clone:Freq) of each clonotypes as axis labels.

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