Fig. 9: Metabolic alternations in Ant2−/− CD8+ T cells. | Nature Communications

Fig. 9: Metabolic alternations in Ant2−/− CD8+ T cells.

From: Metabolic reprogramming driven by Ant2 deficiency augments T Cell function and anti-tumor immunity in mice

Fig. 9

1) Ant2 deficiency leads to a reduction in mtATP transfer to the cytosol, accompanied by a concomitant decrease in ADP concentrations within the mitochondrial matrix. 2) Functionality of the ATP-synthase complex is hindered, resulting in mitochondrial membrane hyperpolarization and OXPHOS inhibition. 3) Increased aerobic glycolysis and proline biosynthesis for NAD+ regeneration. 4) Increased PC activity as a result of PDH inhibition. 5) Increased cataplerosis (TCA-cycle derived amino-acids). 6) Increased anti-oxidative stress machinery and NADPH consumption. 7) Increased phosphate pentose pathway activity due to increased NADPH consumption.

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