Fig. 2: Genome-wide Directions of Effect of Any CHIP and CHIP Subtypes.
Volcano plots showing the effect size (β) and -log10(P-value) from the multiracial meta-analysis of epigenome-wide association studies (EWAS) for (a) any CHIP (Clonal Hematopoiesis of Indeterminate Potential), (b) DNMT3A CHIP, (c) TET2 CHIP, and the EWAS in the Framingham Heart Study (FHS) for (d) ASXL1 CHIP. Genes annotated to the CpG sites are shown. For panels (a–c), the effect size (β) and P-values were derived from fixed-effect meta-analysis of multiple cohorts. For panel (d), because ASXL1 CHIP was only available in the FHS cohort, the effect size (β) and P-values were derived from linear regression models. The color green indicates a significant negative association between CHIP and DNA methylation while purple indicates a positive association between the two variables. Yellow signifies non-significant associations between CHIP and DNA methylation. Two-sided tests were used for all analyses. P-values were adjusted for multiple comparisons using the Benjamini-Hochberg false discovery rate (FDR) method. Significant associations were defined as FDR < 0.05. Exact P-values, standard errors for the β, and 95% confidence intervals for significant results are provided in Supplementary Data 7-10. Source data are provided as a Source Data file.
