Fig. 1: Cross-modal generalization in mice.
a Illustration of the common organization of the peri-personal space for visual and whisker tactile inputs in mice. b Schematic of the behavioral Go/No go paradigm for studying cross-modal generalization of spatial information in mice. c Two types of tactile-to-visual modality switches: “rule-preserving”, wherein the spatial location of rewarded stimuli is preserved, and “rule-reversing”, wherein the location of rewarded stimuli is reversed. d Left: example of a session with the tactile task the day before modality switch. Conditional lick probabilities over trials are shown for the top whisker (blue), the bottom whisker (red) and in absence of stimuli (purple). Task performance (green) is computed as the percentage of correct discrimination trials (see “Methods“). Chance level is shown as a gray dashed line. Traces were computed on a sliding window of 60 trials. Right: same as left for the first visual session following a rule-preserving modality switch. e Left: task performance and conditional lick probabilities averaged across mice (N = 5 mice) over three consecutive sessions before and after a rule-preserving switch (vertical dashed line). Shaded area: S.E.M. Color code as in panel d. Right: detection (purple) and discrimination (green) performance distribution for the session before and after the switch (two-sided paired t test comparing days, Det.: N.S. p = 1; Discr.: N.S. p = 0.96). Performances are also tested against chance level (two-sided t test, Det.: ***p = 4.4 × 10–4 and ***p = 1.4 × 10–7; Discr.: ***p = 2.8 × 10–4 and ***p = 4.7 × 10–4). Error bars: S.E.M. Discrimination performance indicates the proportion of trials in which mice correctly responded to top and bottom stimuli. Detection performance indicates the proportion of trials in which mice differentiated any stimulus (top or bottom) from no stimulus at all (see “Methods“). f, g Same as in panels d-e but for a rule-reversing modality switch (two-sided paired t test comparing days, Det.: ***p = 1.2 × 10–5; Discr.: **p = 0.005). Performances are also tested against chance level (two-sided t test,Det.: ***p = 4.6 × 10–4 and *p = 0.03; Discr.: **p = 0.003 and Blank p = 0.29).
