Fig. 6: Diagrammatic Illustration of the Discovery.
From: Perturbing local steroidogenesis to improve breast cancer immunity
The graphical illustration shows how local steroidogenesis affects anti-tumour immunity in TNBC. In the TNBC environment (left), steroid-producing immune cells promote tumour growth by fostering immunosuppressive elements like Tregs and tumour-associated macrophages (TAMs). In contrast, steroid inhibition (right) boosts anti-tumour immunity, enhancing CD8+ T cell and M1 macrophage activity, and restoring co-stimulation in DCs, which limits tumour growth. This suggests targeting steroidogenesis as a potential therapeutic strategy in TNBC.
