Fig. 7: TRZ-1/BPO NPs for liver tumor imaging.
From: White light-excited organic room-temperature phosphorescence for improved in vivo bioimaging
a, c Phosphorescence images showing the maximal phosphorescence intensities of TRZ-1/BPO NPs (1 mg/mL) after incubation with various a metal ions and c tissue homogenates after white-light pre-irradiation for 2 min. b, d Quantitative analysis of the phosphorescence intensities in (a) and (c). Data mean ± SD (n = 3, independent samples), ***p < 0.001 compared with PBS group in (b) and Zn2+, Ca2+, K+, Cu2+, Mg2+ and Na+ groups in (d). e Phosphorescence imaging of the liver of tumor-bearing mice received intravenous injection with TRZ-1/BPO NPs. f Quantitative data from afterglow image-guided tumor resection in (e), data mean ± SD (n = 3, independent samples), **p < 0.01 compared with unguided surgery group. Insert: H&E staining image of liver tissue for liver cancer model. Scale bar = 200 μm. Statistical significance was calculated using one-way ANOVA in (b, d) and two-tailed Student’s t test in (f). p = 2.53 × 10−10 for heart, 3.39 × 10−10 for liver, 3.92 × 10−10 for spleen, 5.11 × 10−10 for blood compared with PBS group in (b). p = 1.16 × 10−3 compared with unguided surgery group in (f).
