Table 1 Viral DNA and RNA levels after CX014442 treatment
From: BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription
Concentration CX014442 (μM) | vDNA detection (n = 900) | vRNA detection (n = 100) | ||||
|---|---|---|---|---|---|---|
Pooled | Non-Reactivated | Reactivated | ||||
Total vDNA spots | % infected | Total vRNA spots | % vRNA+ cells | Total vRNA spots | % vRNA+ cells | |
0 (control) | 606 | 29.11 | 139 | 34.00 | 1039 | 57.00 |
2.35 | 475 | 25.11 | 254 | 29.00 | 1038 | 34.00 |
4.70 | 462 | 28.33 | 57 | 19.00 | 836 | 33.00 |
9.42 | 229 | 16.22 | 38 | 5.00 | 135 | 33.00 |
18.83 | 293 | 19.00 | 28 | 18.00 | 131 | 6.00 |
HIV- (NC) | 3 | 8.11 | ||||
