Fig. 5: SARS-CoV-2 infection in infants is associated with increased ISGhi transitional and naive B cells. | Nature Communications

Fig. 5: SARS-CoV-2 infection in infants is associated with increased ISGhi transitional and naive B cells.

From: SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses

Fig. 5: SARS-CoV-2 infection in infants is associated with increased ISGhi transitional and naive B cells.The alternative text for this image may have been generated using AI.

a UMAP plots representing B cell subclusters (SCs; n = 5) and patient groups (G1, G2, G3 or pHC). b Heat map representing scaled expression values of selected marker genes defining each of the B cell SC (Supplementary Data 6i). c Boxplot comparing the proportion of each B cell-SC (n = 5) across the individuals (n = 40). pCoV patient groups (G1, G2 and G3) are shown in purple, and pHC in green. P values were calculated using a two-sided t-test comparing the mean (G1, G2 or G3) with mean (pHC). ns: non-significant. The upper and lower bounds represent the 75% and 25% percentiles, respectively. d Bar plot showing the cell frequency of each B cell SC across the 40 individuals, as categorized by patient groups (G1, G2 and G3; in purple) and pHC in green. e As in (a) in plasma cells. f UMAP plots representing scaled expression values of selected marker genes. g As in (c) in plasma cells.

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