Fig. 5: Decreased levels of Kcnh7 in PV and SST interneurons within the ACC of Shank3 KO mice. | Nature Communications

Fig. 5: Decreased levels of Kcnh7 in PV and SST interneurons within the ACC of Shank3 KO mice.

From: Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice

Fig. 5: Decreased levels of Kcnh7 in PV and SST interneurons within the ACC of Shank3 KO mice.The alternative text for this image may have been generated using AI.

a, b t-SNE plots of WT and Shank3 KO groups showing cell clusters, including oligodendrocyte (Oligo), oligodendrocyte precursor cell (OPC), endothelial cell (EC), interneuron (IN), and excitatory neuron (Exc). c Feature plots showing single-cell gene expression of known inhibitory neuron markers (Pvalb, left; Sst, right). d Volcano plot showing that Kcnh7 is one of the downregulated differentially expressed genes in Shank3 KO mice compared to the WT mice in PV interneurons, identified by scRNA-seq (left). Relative mRNA expression showing that Kcnh7 is more prominently in Pvalb-positive neurons compared to Kcnh6 and Kcnh2 (right, n = 14 cells from 2 mice: Kruskal‒Wallis H test, Χ2 = 24.783, P < 0.0001). e Same as (d) but for Sst neurons (n = 19 cells from 2 mice; Kruskal‒Wallis H test, Χ2 = 41.128, P < 0.0001). All statistical tests are two-sided. Data are presented as mean ± SEM. ***P < 0.001, ****P < 0.0001. Source data are provided as a Source Data File.

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