Fig. 2: Relationships between alcohol consumption and blood cell trait variances. | Nature Communications

Fig. 2: Relationships between alcohol consumption and blood cell trait variances.

From: Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction

Fig. 2: Relationships between alcohol consumption and blood cell trait variances.The alternative text for this image may have been generated using AI.

a LocuzZoom plot of variance QTL mapping for platelet crit (pct) variance at ALDH2 gene (Levene’s test, see “Methods”); (b) Mendelian randomization (MR) of alcohol consumption on variance of blood cell traits using GSMR31, MR-PRESSO (presso)34 and weighted-median (wm)35. Diamonds: significant in 3 methods. c Effects of MR of alcohol consumption on variance of corpuscular haemoglobin concentration (mscv); d Effects of MR of alcohol consumption on variance of corpuscular volume variance (mcv). Dashed fitted lines indicate the coefficient of Mendelian Randomisation (bxy = 0.07, sexy = 0.019 for mscv and bxy = 0.064, sexy = 0.0188 for mcv). In panels (c, d), multi-test adjusted p values are shown. All analyses used UK Biobank data with sample size ~N ~ 408,111. In panels (b–d), data are presented as mean values ± SEM. Full names of blood cell traits can be found in Supplementary Data 1.

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