Fig. 9: Spp1 knock out decreases metastatic burden.
From: SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases
A Presence of RIL-175 metastatic liver tumor comparing in Spp1 KO (n = 5) compared to WT mice (n = 7); p = 0.0289. B Number of metastatic surface nodules comparing Spp1 KO (n = 5) compared to WT mice (n = 7); p = 0.0238. Experiments (A, B) were completed in male and female B6.129S6(Cg)-Spp1tm1Blh/J 6–8 week old mice. Data was analyzed using two-sided unpaired t test (A-B): *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001, ns = not significant (data are presented as mean values +/− SEM).
