Fig. 2: Nageotte nodule axons express nociceptive, but not sympathetic markers. | Nature Communications

Fig. 2: Nageotte nodule axons express nociceptive, but not sympathetic markers.

From: Nageotte nodules in human dorsal root ganglia reveal neurodegeneration in diabetic peripheral neuropathy

Fig. 2: Nageotte nodule axons express nociceptive, but not sympathetic markers.The alternative text for this image may have been generated using AI.

A Tyrosine hydroxylase (TH, red) labeling in combination with peripherin (green) and DAPI (blue) revealed that Nageotte nodule axonal sprouts were not sympathetic in origin. Sample size: DPN n = 9. B TrpV1 fibers at a Nageotte nodule in a DPN DRG (white arrow). TrpV1 was only detected in Nageotte nodules from a single DPN donor out of 5 that were investigated. The TrpV1+ fibers at the Nageotte nodule appeared to arise from a glomerulus (magenta arrow). Sample size: DPN n = 5. C Nav1.7 (red) was detected in the axonal fibers intertwined with Nageotte nodules. Sample size: DPN n = 6. Scale bars: A: 10 μm. B: 20 μm. C: 10 μm.

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