Fig. 3: SFTSV differentially regulates core immune and stress pathways in infected R. microplus BME6 cells. | Nature Communications

Fig. 3: SFTSV differentially regulates core immune and stress pathways in infected R. microplus BME6 cells.

From: Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors

Fig. 3: SFTSV differentially regulates core immune and stress pathways in infected R. microplus BME6 cells.

a–c Heat map showing the log2Fold Change (log2FC) of transcripts and log2 Difference (log2D) of proteins from core immune pathways Toll (a), Imd, JNK (b) and JAK-STAT (c) of BME6 cells infected with SFTSV. mRNA and protein expression were normalized to mock-infected BME6 cells. Associated with their schematic representation, blue in Toll pathway (a), green Imd (b), yellow JNK (b), and orange JAK-STAT (c) (Created in BioRender. Petit, M. (2025) https://BioRender.com/7s5zb8h). Dashed line represents a missing protein. d, e Heat map showing the log2FC of transcripts and log2D of proteins related to antiviral functions (d) and stress-related pathways (e) in BME6 cells following SFTSV infection. mRNA and protein expression were normalized to mock-infected BME6 cells. For all panels, heat map gene names in bold represent significantly differentially expressed genes and/or proteins, and gray squares represent genes with no differential expression. Source data are provided as Source Data file.

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