Fig. 3: Relationship between DNA methylation and gene expression at two genomic loci in adipose tissue.
From: Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity
a Correlation between methylation at cg19998400 and SH3BP4 expression (n = 80 individuals), showing the distribution of cg19998400 on top and SH3BP4 expression on right. b Correlation between methylation at cg17468563 and DHRS3 expression (n = 80 individuals), showing the distribution of cg17468563 on top and DHRS3 expression on right. Red lines in indicate fitted linear regression lines. c Variation in SH3BP4 and DHRS3 expression explained by methylation at cg19998400 and cg17468563 (yellow bars), respectively, and combined with common familial factors (genetic or environmental) (blue bars) (n = 80 individuals). Source data are provided in the Source Data file. DNAme DNA methylation, L2PM = log2-counts per million; r = Pearson correlation coefficient; *** p < 0.001.
