Fig. 2: Brain metastasis spatial distribution and morphology by coarse anatomical regions.

A Brain metastasis risk levels (color-coded localized incidence risk of brain metastases) displayed on axial slices of the MNI model (grayscale) for patients with lung primary (N = 1323 patients, L = 5334 lesions) cancer, first diagnosis of brain lesions prior to stereotactic treatment. B Percentage contribution of BM lesions by coarse anatomical regions for lung (N = 1315 patients, L = 5230 lesions), breast (N = 570 patients, L = 3007 lesions), and melanoma (N = 407 patients, L = 1931 lesions) primary cancer. The cumulative lesion contribution of all brain regions represents 100%. Error bars indicate 95% confidence interval over the four institutions represented in the dataset. The center of the error bars represents the mean percentage contribution of all four institutions for a given structure. C Percentage contribution of brain metastasis normalized by the volume by coarse anatomical regions for lung (N = 1315 patients, L = 5230 lesions), breast (N = 570 patients, L = 3007 lesions), and melanoma (N = 407 patients, L = 1931 lesions) primary cancer. Error bars indicate 95% confidence interval over the four institutions represented in the dataset. The center of the error bars represents the mean percentage contribution normalized by the volume of all four institutions for a given structure. D Percentage of the brain lesion contribution as a function of the minimum distance of the lesion centroid to the white and gray matter interface. Error bars indicate 95% confidence interval over the four institutions represented in the dataset (N = 2113 patients, L = 8176 lesions). The center of the error bars represents the mean percentage contribution of all four institutions for a specific distance to the white-gray matter junction. The white and gray matter volumes are represented by yellow and light blue, respectively. The dark blue represents the edge of the brain’s gray matter. E Lesions sphericity distribution as a function of the lesion volume (N = 2001 patients, L = 9302 lesions), where the heatmap represents the magnitude of the count in the plotted joint histogram distribution. Source data are provided as a Source Data file.