Fig. 4: Brain metastasis spatial distribution by level of perfusion and arterial territories.

A Left- illustration of brain vascular levels: artery, arteriole, and capillary. Center/right—representative arterial spin labeling image on representative axial and coronal slices on the MNI model. B Percentage contribution of brain metastasis lesions by MNI population arterial territories for lung (N = 1316 patients, L = 5224 lesions), breast (N = 565 patients, L = 2998 lesions), and melanoma (N = 406 patients, L = 1954 lesions) primary cancer. Error bars indicate 95% confidence interval over the four institutions represented in the dataset. The center of the error bars represents the mean percentage contribution of all four institutions for a given structure. Percentage contribution of brain metastasis in sub-arterial territories combined into anterior and posterior arterial territories for lung, breast, and melanoma primaries. C Percentage contribution of brain metastasis normalized by the volume by MNI arterial territories for lung (N = 1316 patients, L = 5224 lesions), breast (N = 565 patients, L = 2998 lesions), and melanoma (N = 406 patients, L = 1954 lesions) primary cancer. Error bars indicate 95% confidence interval over the four institutions represented in the dataset. The center of the error bars represents the mean percentage contribution normalized by the volume of all four institutions for a given structure. D Brain metastasis volume and count per voxel as a function of normalized brain perfusion on the MNI model. Color map indicates total brain volume within the joint histogram bin. E Brain metastasis volume plotted with the minimum white–gray matter distance as a function of normalized brain perfusion of the MNI model. ACA anterior cerebral artery, MCAF frontal pars of middle cerebral artery, MCAP parietal pars of middle cerebral artery, PCAO occipital pars of posterior cerebral artery, MCAT temporal pars of middle cerebral artery, IC inferior cerebellar, LLS lateral lenticulostriate, SC superior cerebellar, MCAO occipital pars of middle cerebral artery, PCAT temporal pars of posterior cerebral artery, B basilar, MCAI insular pars of the middle cerebral artery, PCTP posterior choroidal and thalamoperfurators, ACTP anterior choroidal and thalamoperfurators, MLS medial lenticulostriate, LV lateral ventricle. Source data are provided as a Source Data file.