Table 1 Demographic, clinical, and brain metastasis characteristics split by the primary cancer for the data accumulated at the four partner institutions

 Patients, n

222

253

248

600

1323

 Lesions, n

664

1016

655

2989

5324

 Age, mean (range)

65 (33−93) (n = 201)

66 (33−89) (n = 151)

65 (29−91)

64 (32−91)

65 (29−93) (n = 1200)

 Sex, n (M/F)

106/116

114/139

120/128

274/326

614/709

 Lesions per patient, median/mean (range)

2/2.99 (1−17)

2/4.02 (1−21)

2/2.64 (1−15)

3/4.98 (1−48)

2/4.02 (1−48)

 Disease volume, mean (range) (cc)

1.561 (0.032−25.541)

0.893 (0.009−43.210)

1.831 (0.007−40.484)

1.108 (0.006−53.620)

1.213 (0.006−53.620)

 Sphericity, mean (range)

0.849 (0.612−0.916)

0.834 (0.545−0.922)

0.831 (0.544−0.912)

0.814 (0.561−0.948)

0.827 (0.544−0.948)

 Histology top 3, n (%)

Adenocarcinoma 209 (94.1)

Squamous Cell 8 (3.6)

Other 3 (1.4)

N/A

Adenocarcinoma 138 (55.6)

Other 88 (35.5)

Squamous Cell 20 (8.1)

Adenocarcinoma 473 (78.8)

Small Cell 31 (5.2)

Carcinoma NOS 31 (5.2)

Adenocarcinoma 980 (76.6)

Other 91 (8.5)

Squamous Cell 59 (5.5)

 Patients, n

87

64

74

348

573

 Lesions, n

382

309

267

2120

3078

 Age, mean (range)

54 (30−81) (n = 81)

58 (33−83) (n = 40)

56 (30−87)

53 (0−79)

54 (30−87) (n = 543)

 Sex, n (M/F)

0/87

1/63

0/74

5/343

6/567

 Lesions per patient, median/mean (range)

2/4.39 (1−18)

4/4.83 (1−19)

2/3.61 (1−18)

4/6.09 (1−44)

3/5.37 (1−44)

 Disease volume, mean (range) (cc)

1.581 (0.019−62.381)

0.913 (0.008−21.640)

1.259 (0.013−16.343)

1.064 (0.002−48.750)

1.151 (0.002−62.381)

 Sphericity, mean (range)

0.833 (0.531−0.914)

0.827 (0.529−0.916)

0.816 (0.504−0.899)

0.805 (0.444−0.922)

0.812 (0.444−0.922)

 Histology top 3, n (%)

Adenocarcinoma 84 (96.6)

Other 2 (2.3)

Unknown 1 (1.1)

N/A

Other 65 (87.8)

Adenocarcinoma 5 (6.8)

Unknown 4 (5.4)

Adenocarcinoma 337 (96.8)

Other 8 (2.3)

Bone 1 (0.3)

Adenocarcinoma 426 (83.7)

Other 75 (14.7)

Unknown 5 (1.0)

 Patients, n

62

56

55

236

409

 Lesions, n

249

287

148

1312

1996

 Age, mean (range)

63 (20−91) (n = 56)

61 (27−85) (n = 31)

59 (23−81)

61 (29−101)

61 (20−101) (n = 378)

 Sex, n (M/F)

40/22

40/16

37/18

147/89

264/145

 Lesions per patient, median/mean (range)

2/4.02 (1−21)

3/5.12 (1−27)

2/2.69 (1−12)

3/5.56 (1−51)

3/4.88 (1−51)

 Disease volume, mean (range) (cc)

1.456 (0.030−38.727)

1.362 (0.005−52.918)

2.385 (0.005−14.842)

1.326 (0.004−33.036)

1.493 (0.004−52.918)

 Sphericity, mean (range)

0.847 (0.683−0.910)

0.837 (0.654−0.906)

0.824 (0.430−0.909)

0.819 (0.502−0.922)

0.825 (0.430−0.922)

 Histology top 3, n (%)

Melanoma 62 (100)

Melanoma 56 (100)

Melanoma 55 (100)

Melanoma 236 (100)

Melanoma 409 (100)

 Patients, n

31

15

19

90

155

 Lesions, n

87

74

39

287

487

 Age, mean (range)

62 (34−87) (n = 27)

68 (54−85) (n = 6)

58 (35−77)

58 (24−81)

59 (24−87) (n = 142)

 Sex, n (M/F)

17/14

8/7

12/7

52/38

89/66

 Lesions per patient, median/mean (range)

1/2.81 (1−13)

3/4.93 (1−14)

1/2.05 (1−7)

2/3.19 (1−14)

2/3.14 (1−14)

 Disease Volume, mean (range) (cc)

2.576 (0.046−16.416)

1.554 (0.007−16.607)

4.922 (0.036−39.471)

2.990 (0.016−44.776)

2.853 (0.007−44.776)

 Specificity, mean (range)

0.840 (0.602−0.913)

0.825 (0.577−0.919)

0.831 (0.669−0.897)

0.825 (0.645−0.919)

0.829 (0.577−0.919)

 Histology top 3, n (%)

Adenocarcinoma 31 (100)

N/A

Adenocarcinoma 14 (73.7)

Other 4 (21.1)

Squamous Cell 1 (5.3)

Adenocarcinoma 67 (74.4)

Carcinoma NOS 12 (13.3)

Squamous Cell 7 (7.8)

Adenocarcinoma 112 (80)

Other 12 (8.6)

Squamous Cell 8 (5.7)

 Patients, n

12

15

25

30

82

 Lesions, n

35

71

75

140

321

 Age, mean (range)

59 (23−82)

62 (43−82) (n = 11)

62 (21−84)

54 (20−78)

58 (20−84) (n = 78)

 Sex, n (M/F)

8/4

4/11

10/15

27/3

49/32

 Lesions per patient, median/mean (range)

2/2.92 (1−10)

3/4.73 (1−14)

2/3.0 (1−11)

2/4.67 (1−26)

2/3.91 (1−26)

 Disease volume, mean (range) (cc)

2.224 (0.109−18.725)

1.407 (0.016−14.684)

2.225 (0.008−23.941)

3.022 (0.016−52.342)

2.401 (0.008−52.342)

 Sphericity, mean (range)

0.859 (0.756−0.904)

0.827 (0.642−0.907)

0.839 (0.655−0.911)

0.820 (0.614−0.904)

0.833 (0.614−0.911)

 Histology top 3, n (%)

Adenocarcinoma 9 (75)

Other 3 (25)

N/A

Other 13 (52)

Adenocarcinoma 9 (36)

Squamous Cell 2 (8)

Carcinoma NOS 12 (40)

Germ Cell Tumor 8 (26.7)

Other 4 (13.3)

Other 20 (29.9)

Adenocarcinoma 18 (26.9)

Carcinoma NOS 12 (17.9)

Patients, n

96

115

67

245

523

Lesions, n

302

349

129

1081

1861

Age, mean (range)

61 (19−88) (n = 86)

60 (24−81) (n = 39)

61 (16−90)

58 (4−88)

59 (4−90) (n = 437)

Sex, n (M/F)

43/53

47/27 (n = 74)

34/33

132/113

256/226 (n = 482)

Lesions per patient, median/mean (range)

2/3.15 (1−19)

2/3.03 (1−18)

1/1.93 (1−8)

3/4.41 (1−32)

2/3.56 (1−32)

Disease volume, mean (range) (cc)

1.549 (0.017−36.346)

1.269 (0.010−25.019)

2.213 (0.037−14.708)

1.638 (0.011−58.960)

1.594 (0.010−58.960)

Sphericity, mean (range)

0.854 (0.676−0.911)

0.835 (0.596−0.911)

0.811 (0.436−0.905)

0.816 (0.544−0.911)

0.825 (0.436−0.911)

Histology top 3, n (%)

Adenocarcinoma 42 (43.8)

Renal cell 30 (31.2)

Other 20 (20.8)

N/A

Other 32 (47.8)

Renal Cell 16 (23.9)

Adenocarcinoma 12 (17.9)

Renal Cell 69 (28.2)

Carcinoma NOS 46 (18.8)

Adenocarcinoma 40 (16.3)

Renal Cell 115 (28.2)

Adenocarcinoma 94 (23.0)

Other 57 (14.0)