Fig. 2: Impact of Her2 staining information on morphological profiles.
From: BiDAC-dependent degradation of plasma membrane proteins by the endolysosomal system
T-SNE cell morphology plots of SKOV3 (A) or SKBR3 (B) cells treated for 6 h with the indicated drugs. T-SNE cell morphology plots generated without Her2 staining data for SKOV3 (C) or SKBR3 (D) cells treated for 6 h with the indicated drugs. Graphical representation of the degree of clustering between active and VHLInactive BiDAC-dependent phenotypes in the presence (E) or absence (F) of Her2 staining information. G Representative fluorescence microscopy images of SKOV3 cells treated with the indicated drugs for 6 h. n = 45,000 cells were imaged for each treatment condition. Scale bar, 20 μm. For T-SNE plots, dose order represents increasing concentrations of drugs.
