Fig. 1: Increased FABP4 levels observed in the serum of PMOP patients and in the bone marrow of OVX mice. | Nature Communications

Fig. 1: Increased FABP4 levels observed in the serum of PMOP patients and in the bone marrow of OVX mice.

From: FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice

Fig. 1

a The OVX mice showed a marked decrease in trabecular bone mass. n = 6 mice per group. b H&E staining on paraffin-embedded tibial sections from OVX mice and Sham mice, with circular gaps representing dissolved adipose tissue. Scale bar, 300 μm and 100 μm. c IHC staining of FABP4 on tibial sections. Scale bar, 50 μm. d Quantification analysis of adipose tissue of (b). n = 4 mice in each group. e Quantification analysis of FABP4 expression of (c). n = 5 mice in each group. f Serum level of FABP4 was increased in PMOP patients and non-OP patients confirmed by ELISA assay. Data represent mean ± SEM; n = 8 for PMOP patients and n = 7 for non-OP patients. g Pearson correlation analysis between BMD and FABP4 in all clinical patients. All data is presented as mean ± SEM with p-values (d–f). Two-tailed unpaired t tests (d–f) and the two-tailed Pearson correlation coefficient (g) were calculated were performed. Source data are provided as Source Data file.

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