Fig. 6: PK data and tissue distribution of BMS in SD rats. | Nature Communications

Fig. 6: PK data and tissue distribution of BMS in SD rats.

From: FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice

Fig. 6

a PK data of three SD rats (101–103) following intravenous administration of BMS at a dose of 2 mg/kg. b PK data of three SD rats (201–203) following oral gavage of BMS at a dose of 10 mg/kg. c, d Tissue distribution of BMS in female (c) and male (d) SD rats at 0.25 h, 1 h, 4 h, and 8 h after oral gavage at a dose of 10 mg/kg. Distribution was assessed in the small intestine, lung, liver, stomach, kidney, heart, bone marrow (highlighted in red and emphasized), ovaries or testes, spleen, large intestine, bladder, adipose tissue, brain, and skeletal muscle. PK parameters included: T1/2 (half-life), Tmax (time to peak concentration), Cmax (maximum concentration), AUC(0–t) (area under the curve from 0 to t), AUC (0–∞) (area under the curve from 0 to infinity), MRT(0–t) (mean residence time from 0 to t), MRT (0–∞) (mean residence time from 0 to infinity), C0 (initial concentration), Vss (volume of distribution at steady state), Vz (apparent volume of distribution), Cl (clearance), F (oral bioavailability). Source data are provided as Source Data file.

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