Fig. 8: Bone-targeting NPs loaded with FABP4 inhibitors effectively alleviate PMOP in vivo. | Nature Communications

Fig. 8: Bone-targeting NPs loaded with FABP4 inhibitors effectively alleviate PMOP in vivo.

From: FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice

Fig. 8

a Schematic illustration of the administration protocol for Ald-BMS-NPs treatment in OVX mice. The scissors, ovary and syringe icons are from templates provided by ChemDraw. n = 6 mice for each group. b Representative 3D reconstructed images of Micro-CT scans of femur from each group. c BMD data of the femur from different groups of mice. n = 4 mice per group. d Results of Micro-CT 3D analysis for BV/TV, Tb.Th, Tb.N and Tb.Sp across different groups. Data represent mean ± SEM; n = 4 mice per group. e Serum markers of liver and kidney function in the various groups of mice, Reference values ranges were obtained from literature53. Data are presented as mean ± SEM, with p-values shown in parentheses. Values exceeding the reference range are highlighted in bold; n = 3 mice per group. All data is presented as mean ± SEM with p-values (c, d), ns = no significance. Data was analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test (c, d). Source data are provided as Source Data file.

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