Fig. 1: Schematic overview of tumors developed by individuals in the CMMRD cohort. | Nature Communications

Fig. 1: Schematic overview of tumors developed by individuals in the CMMRD cohort.

From: Unraveling mutagenic processes influencing the tumor mutational patterns of individuals with constitutional mismatch repair deficiency

Fig. 1

Siblings are connected by a bracket. For each individual, malignancies, including relapses (R) and metastases (M), and the occasions at which liver or GI adenomas were detected during surveillance are indicated on a timeline according to age at diagnosis. The death of an individual is indicated by a vertical dash at the end of the timeline. For tumors marked with a white dot, material was collected and sequenced. Individual C19 was diagnosed with seven simultaneous colorectal adenocarcinomas, all of which were sequenced. Previous studies have described individuals C03 and C0462, C01 and C0663, C09 and C2064, C02, C04, C05, C06, C08, C12, C16 and C1765, C1166,67 and C107. Source data are provided as a Source Data file.

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