Fig. 7: Induction of anti-MPXV neutralizing and protective antibodies in rhesus macaques. | Nature Communications

Fig. 7: Induction of anti-MPXV neutralizing and protective antibodies in rhesus macaques.

From: Mpox multiprotein virus-like nanoparticle vaccine induces neutralizing and protective antibodies in mice and non-human primates

Fig. 7

a The pooled serum from rhesus macaques immunized in Fig. 6 with a total of 30 µg of a mixture of the three monovalent VLPs or 0.5 ml of Jynneos vaccine subcutaneously at 3-week intervals was injected into CAST mice one day before challenge with 104 PFU of MPXV clade IIa. b Anti-MPXV neutralizing titers were determined in duplicate for serum of individual macaques obtained prior to immunizations (Preimmune) or 3 weeks after each immunization with Jynneos or VLPs. Bars indicate geometric means. Significance between preimmune and immune sera determined by Kruskal-Wallis/Dunn’s multiple comparison test. c CAST mice (n = 6 per group) were injected IP with 0.5 ml of pooled preimmune serum or serum pooled from animals following boost 3 with Jynneos or VLPs. Weight loss and survival were determined following the IN challenge of CAST mice with 105 PFU of MPXV. Bars represent SD. Source data is provided as a Source Data file. Created in BioRender. Moss (2025) https://BioRender.com/u3e5g0y.

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