Fig. 1: Working hypothesis. | Nature Communications

Fig. 1: Working hypothesis.

From: Trifluoroethanol-assisted asymmetric propargylic hydrazination to α-tertiary ethynylhydrazines enabled by sterically confined pyridinebisoxazolines

Fig. 1

a Selected bioactive molecules containing chiral α-tertiary hydrazine. b Known strategies for catalytic asymmetric synthesis of α-tertiary hydrazine. c Our previous work on Cu-catalyzed asymmetric propargylic amination enabled by sterically confined PYBOX ligands. d This work, enantioselective propargylic hydrazination to generate α-tertiary ethynylhydrazines.

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