Fig. 6: Immunohistochemical patterns of β-catenin in salivary gland basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC). | Nature Communications

Fig. 6: Immunohistochemical patterns of β-catenin in salivary gland basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC).

From: Wnt/β-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma

Fig. 6

a Case PD56510a, a BCA with a CTNNB1 p.I35T mutation, demonstrating patchy nuclear β-catenin expression in both abluminal basal cells and stromal cells. Scale bar: 200 µm. b Case PD52381a, a BCA with a FBXW11 p.517S mutation, exhibiting patchy nuclear β-catenin expression in a random pattern, along with focal nuclear expression in stromal cells. Scale bar: 100 µm. c Normal salivary gland exocrine gland cells from case PD52386a, with membranous β-catenin expression. Scale bar: 50 µm. d Case PD56517a, a BCA without a CTNNB1 or FBXW11 mutation, exhibiting membranous β-catenin expression. Scale bar: 100 µm. e Case PD56543a, a BCAC with a FBXW11 p.517S mutation, showing patchy, random nuclear β-catenin expression. Scale bar: 200 µm. f Case PD56526a, a BCAC showing only membranous β-catenin expression. Scale bar: 200 µm.

Back to article page