Fig. 3: Meta-analysis of 21 traits across KCPS2, KoGES, BBJ, TWB, and UKB. | Nature Communications

Fig. 3: Meta-analysis of 21 traits across KCPS2, KoGES, BBJ, TWB, and UKB.

From: Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures

Fig. 3: Meta-analysis of 21 traits across KCPS2, KoGES, BBJ, TWB, and UKB.

a Genome-wide significant loci identified in the meta-analysis, Color of dots indicate significance in meta-analysis (black), KCPS2 (blue), KoGES (orange), BBJ (purple), TWB (light blue), and UKB (green). Multiple dots in a bar represent simultaneous significance in multiple cohorts. b Comparisons of allele frequency and effect sizes in KCPS2 for the genome-wide significant variants discovered only in KCPS2 (blue) versus those identified only in the meta-analysis (black). c Comparisons of effect sizes in KCPS2 and study-specific effect sizes for the lead variants at the 12,224 meta-analysis genome-wide significant loci. The solid lines were estimated by spline smoothing from generalized additive model (b) or linear regression model (c). The error bars (b and c) indicate 95% confidence intervals estimated as ±1.96 × standard error. Full meta-analysis results are shown in Supplementary Data 6, 7.

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