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Fig. 3: Iterative forward genetic Mirror screening to identify factors required for MALAT1 3′-end processing, as well as factors blocked from degrading MALAT1 by its triple-helical 3′-end ENE element. | Nature Communications
Fig. 3: Iterative forward genetic Mirror screening to identify factors required for MALAT1 3′-end processing, as well as factors blocked from degrading MALAT1 by its triple-helical 3′-end ENE element.
a Genome-wide iterative FACS-based forward genetic screening in the “Red” (Fig. 1e) Mirror reporter cell line (analogous screening in the orthogonal “Green” Mirror cell line is shown in Fig. S1c). b Schematics of iterative forward genetics screening rounds employed in (a) and Fig. S1c.
