Table. 1 Characterisation of patisiran LNP and LNP X

From: Efficient mRNA delivery to resting T cells to reverse HIV latency

 

Patisiran LNP

LNP X

p value

Z-average (d.nm)

90.8 ± 6

105.8 ± 5

0.110

Size by Number distribution (d.nm)

61.2 ± 5

73.6 ± 4

0.112

PDI

0.10 ± 0.02

0.10 ± 0.01

0.995

Encapsulation efficiency (%)

96.2 ± 6

96.4 ± 2

0.847

  1. Z-average (hydrodynamic diameter), mean size determined by Number distribution and LNP size uniformity (polydispersity index, PDI) as determined by dynamic light scattering for the patisiran LNP or LNP X formulation encapsulating mRNA for mCherry. mRNA encapsulation efficiency for both formulations was determined using a modified RiboGreen assay. Mean ± SEM for n = 4-5 LNP batches for each formulation. P values determined using two-tailed unpaired t test.
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