Fig. 3: Product transformations.
From: Modular access to alkylfluorides via radical decarboxylative-desulfonylative gem-difunctionalization
a The synthesis of 4. Reaction conditions: (1) 3a (0.1 mmol), 4 Å molecular sieves powders (150 mg), Me3OBF4 (0.5 mmol), CH2Cl2, 10 min; (2) MeOH (1 mL), 0 °C, NaBH4 (0.25 mmol); (3) AgNO3 (0.3 mmol), CH3CN (1.5 mL)/H2O(0.18 mL). Further transformations of 4. Reaction conditions: 4 (0.1 mmol). b DAST (1.2 equiv), rt, 4 h; c Na2HPO4 (1.2 equiv), m-CPBA (3 equiv), 0 oC, 12 h; d (1) NaBH4 (1.2 equiv), MeOH, rt, 4 h; (2) DAST (1.2 equiv), CH2Cl2, rt, 8 h; e MoO2Cl2 (5 mol %), N2CHCOOEt (1.2 equiv), CH2Cl2, 30 °C. Isolated yields are shown.
