Fig. 6: Schematic representation of the pathophysiological importance of the skin renin-angiotensin system (RAS) in angiotensin II (Ang II)-induced hypertension. | Nature Communications

Fig. 6: Schematic representation of the pathophysiological importance of the skin renin-angiotensin system (RAS) in angiotensin II (Ang II)-induced hypertension.

From: Keratinocyte-specific angiotensin II receptor-associated protein deficiency exacerbates angiotensin II-dependent hypertension via activation of the skin renin-angiotensin system

Fig. 6

Keratinocyte-specific Ang II type 1 receptor (AT1R)-associated protein (ATRAP) deficiency elicits downregulated AT1R internalization, which is associated with local RAS activation in the skin. In skin lacking ATRAP, Ang II-induced angiotensinogen production is accelerated through activating the Ang II-AT1R axis in keratinocytes, which may contribute to increased Ang II levels in the skin and exacerbated Ang II-induced hypertension through enhanced skin vasoconstriction. Figure partially created in BioRender. Taguchi, S. (2025) https://BioRender.com/c54c658.

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