Table 2 Analysis of sodium and water contents in the skin and total body of angiotensin II (Ang II)-infused control (Ctrl) and keratinocyte-specific ATRAP knockout (KO) mice

From: Keratinocyte-specific angiotensin II receptor-associated protein deficiency exacerbates angiotensin II-dependent hypertension via activation of the skin renin-angiotensin system

Variable

Ctrl + Ang II

KO + Ang II

P-value

No. of samples

11

12

 

Skin wet weight (g)

3.34 ± 0.26

3.19 ± 0.29

0.2092

Skin dry weight (g)

1.49 ± 0.07

1.42 ± 0.11

0.0782

Skin sodium content (mmol)

0.227 ± 0.028

0.215 ± 0.024

0.2956

Skin sodium content (mmol/gDW)

0.152 ± 0.016

0.152 ± 0.019

0.9724

Skin water content (mL)

1.85 ± 0.21

1.77 ± 0.25

0.4319

Skin water content (mL/gDW)

1.24 ± 0.11

1.25 ± 0.19

0.8320

Total body wet weight (g)

17.16 ± 0.80

17.08 ± 0.85

0.8066

Total body dry weight (g)

6.35 ± 0.21

6.42 ± 0.37

0.5703

Total body sodium content (mmol)

1.022 ± 0.100

1.082 ± 0.084

0.1336

Total body sodium content (mmol/gDW)

0.161 ± 0.023

0.169 ± 0.017

0.2864

Total body water content (mL)

10.82 ± 0.70

10.66 ± 0.84

0.6294

Total body water content (mL/gDW)

1.71 ± 0.10

1.67 ± 0.17

0.5355

  1. Data are expressed as means ± standard deviation and were analyzed using a two-sided unpaired t test; *P < 0.05, **P < 0.01, ***P < 0.001 vs. Ctrl. DW, dry weight.
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