Fig. 1: Discovered loci for individual metabolites.
From: Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers
a Scatterplot displaying the effect sizes (y-axis) of all 15,585 locus lead variants identified through univariate genome-wide association study (GWAS) of 249 metabolites, ordered by their minor allele frequency (x-axis) and colour coded by metabolite category. The two loci with the strongest effects on individual GWAS are demarcated by vertical dashed lines and annotated. On the right side of the figure, the local genomic regions of these two loci are depicted, with b showing rs7412 mapped to APOE and c showing rs1047891 mapped to CPRS1, both of which were also the only fine-mapped variants in these regions. The chromosomal location is on the x-axis and -log10(p-value) on the y-axis, with colours reflecting the linkage disequilibrium between the lead and surrounding variants, as indicated in the legend. The bottom panel shows the genes located in these regions. The vertical dashed lines highlight the position of the lead variants in their respective genes.
