Fig. 3: Functional annotation of gene-based tests.
From: Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers
a Stacked bar plot summarizing the output of tests of tissue-specific gene expression, with the top 15 tissues on the x-axis. b Competitive gene-set analysis of Gene Ontology biological processes, with top 15 pathways listed on the x-axis. For both plots, the number of significant associations with metabolites is shown on the y-axis and the colours indicate metabolite categories. c Venn diagram of the number of genes identified through gene-based tests of the multivariate GWAS, univariate GWAS and rare variant WES data.
