Fig. 4: Development of catalytic variants broadened the scope and resulted in faster reactions. | Nature Communications

Fig. 4: Development of catalytic variants broadened the scope and resulted in faster reactions.

From: Nucleophilic aromatic substitutions enable diversity-oriented synthesis of heterocyclic atropisomers via non-atropisomeric intermediates

Fig. 4

a Fluoride-catalyzed reactions starting with H1-Si (Method B) or with H1 in presence of Me3SiCF3 (Method C) are remarkably fast. b Proposed catalytic cycles. c Method B enabled synthesis of atropisomers which could not be synthesized efficiently by Method A. d Method C enabled synthesis of atropisomers which could not be synthesized efficiently neither by Method A nor B. For additional scope by Method C, see Supplementary Section 5.3. e Catalytic methods foreshadow atroposelectivity, as shown by use of a benchmark chiral fluoride-based catalyst. TBAT tetrabutylammonium difluorotriphenylsilicate.

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