Fig. 10: Decreased RNF20 levels correlate with increased levels of HIF1α and glycolytic enzymes in AD and SCLC patients.
From: RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α
a Immunohistochemistry of tissue samples from different types and grades of lung tumors from a tissue microarray stained with HIF1α, ENO1 and LDHA antibodies. Scale bars, 100 µm. b Pearson correlation (r) of the relative staining intensity (H-Score) of RNF20 and HIF1α (top panels), RNF20 and ENO1 (middle panels), and RNF20 and LDHA (bottom panels) in AD and SCLC patients, with a two-sided p-value computed using the t-distribution. n = 70 for AD; n = 22 for SCLC. c Schematic model of the function of RNF20 in lung SCLC and AD development. PNEC pulmonary neuroendocrine cell, AT1 alveolar type 1 cell, AT2 alveolar type 2 cell, RNAPII RNA polymerase II. The figure was created in BioRender68.
