Fig. 2: Vesicle properties of M. smithii ALI, M. intestini, M. smithii GRAZ-2, and M. stadtmanae.
From: Proteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea
a Vesicle size [nm]: A one-way ANOVA followed by Tukey’s HSD post hoc test revealed significant differences between M. smithii ALI and M. intestini (p = 0.046), as well as M. intestini and M. smithii GRAZ-2 (p = 0.007). No significant differences were observed for other comparisons. b Vesicle concentration [particles/ml]: No statistically significant differences were found between strains via one-way ANOVA and Tukey’s HSD post hoc test (p > 0.05). Protein (c) was normalized to [µg/1010 particles], and DNA (d) and RNA (e) content to [ng/1010 particles] (Supplementary Data 3): A Kruskal-Wallis test was applied to DNA content (d), while one-way ANOVA and Tukey’s HSD post hoc tests were performed for protein (c) and RNA (e) content. No significant differences were observed between strains for c, d or e. One outlier was removed for d and e. Dots represent the number of biological/technical replicates (Supplementary Data 2): M. smithii ALI, n = 10/52; M. intestini = 12/52; M. smithii GRAZ-2 = 5/26; M. stadtmanae = 6/17. The line inside the boxplot indicates the median, while the box spans the first to third quartile; whiskers represent the smallest and largest values within 1.5× the interquartile range. One asterisk represents p < 0.05, ** represents p < 0.01. Source data are provided as a Source Data file.
