Fig. 1: KAP1 and HP1 are enriched at endogenous retroelements in mouse embryonic stem cells. | Nature Communications

Fig. 1: KAP1 and HP1 are enriched at endogenous retroelements in mouse embryonic stem cells.

From: The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

Fig. 1: KAP1 and HP1 are enriched at endogenous retroelements in mouse embryonic stem cells.The alternative text for this image may have been generated using AI.

a–c Correlation plots between HP1 proteins genome-wide at 5 kb bins in ESCs. Spearman correlation tests were used to determine statistical significance. Correlation plots between KAP1 and (d) HP1α, (e) HP1β and (f) HP1γ genome-wide at 5 kb bins in ESCs. Spearman correlation tests were used to determine statistical significance. g ChIP-seq enrichment of heterochromatic histone modifications and factors, including HP1 proteins, mapped to the repetitive genome. Data are represented in a hierarchically (Spearman rank) clustered heatmap of z-score fold enrichment (red) or depletion (blue) over a matched input. See Supplementary Fig. 1 for complete heatmap. h Genome browser representations of enrichment of heterochromatic histone modifications and factors, including HP1 proteins, in ESCs at IAPEz (left), MERVK10C (center) and ETn (right). The y-axis represents read density in counts per million mapped reads (CPM). Average profiles (top) and heatmaps (bottom) of KAP1, HP1α, HP1β and HP1γ enrichment at (i) IAPEz (n = 2,438), (j) MERVK10C (n = 2,074) and (k) ETn (n = 1,116) in ESCs. Data are centered on the LTR with 1.5 kb upstream and 8 kb downstream of the LTR displayed for each analysis.

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