Fig. 4: Bioenergetic stress potentiates persistence via the stringent response.
From: Bioenergetic stress potentiates antimicrobial resistance and persistence
a Ciprofloxacin lethality in wildtype MG1655 and ∆ETC cells following treatment with 16 ng/mL ciprofloxacin. b Ciprofloxacin lethality in pEmpty, pF1, and pNOX cells following treatment with 18 ng/mL ciprofloxacin and 12.5 µM piceatannol (PA). c Ciprofloxacin lethality in pEmpty, pF1, and pNOX cells following treatment with 18 ng/mL ciprofloxacin and 15 µ/mL catalase (CAT). d Ciprofloxacin lethality in ∆relA ∆spoT cells expressing pEmpty, pF1, or pNOX following treatment with 18 ng/mL. e Ciprofloxacin lethality in ∆rpoS cells expressing pEmpty, pF1, or pNOX following treatment with 18 ng/mL ciprofloxacin. Data reported as change in colony-forming units (CFUs) relative to time 0 for all time-kill experiments. Data represent biological replicates (independent cultures) and are depicted as mean ± 95% CI. All experiments performed in MOPS-rich media. n = 4 for all experiments. Source data are provided within the ‘Source Data.xlsx’ file.
