Table 2 Treatment-related adverse events

From: Anlotinib plus toripalimab as a first-line treatment in patients with advanced gastric cancer and performance status 2: the phase II APICAL-GC trial

Adverse Event

N

Grade 1

Grade 2

Grade 3

Grade 4

Hypothyroidism

9 (37.5%)

7 (29.2%)

2 (8.3%)

  

AST elevation

6 (25%)

1 (4.2%)

1 (4.2%)

4 (16.6%)

 

Pain

6 (25%)

5 (20.8%)

1 (4.2%)

  

Diarrhea

5 (20.8%)

2 (8.3%)

3 (12.5%)

  

Fatigue

5 (20.8%)

4 (16.6%)

1 (4.2%)

  

Rash

5 (20.8%)

4 (16.6%)

1 (4.2%)

  

Hypertension

4 (16.6%)

2 (8.3%)

 

2 (8.3%)

 

Nausea

3 (12.5%)

2 (8.3%)

1 (4.2%)

  

Hand-Foot syndrome

2 (8.3%)

1 (4.2%)

 

1 (4.2%)

 

Proteinuria

2 (8.3%)

2 (8.3%)

   

Granulocytopenia

2 (8.3%)

1 (4.2%)

 

1 (4.2%)

 

Thrombocytopenia

2 (8.3%)

1 (4.2%)

 

1 (4.2%)

 

Anemia

2 (8.3%)

  

2 (8.3%)

 

mucositis

2 (8.3%)

1 (4.2%)

1 (4.2%)

  

Edema

2 (8.3%)

2 (8.3%)

   

Abdominal distension

1 (4.2%)

1 (4.2%)

   

Elevated bilirubin

1 (4.2%)

1 (4.2%)

   

Elevated creatinine

1 (4.2%)

1 (4.2%)

   

Fever

1 (4.2%)

1 (4.2%)

   

Hyperamylasemia

1 (4.2%)

1 (4.2%)