Fig. 2: Oxidative and abundance changes of glucose and methylglyoxal metabolic enzymes in lung cancer patients. | Nature Communications

Fig. 2: Oxidative and abundance changes of glucose and methylglyoxal metabolic enzymes in lung cancer patients.

From: Increased antioxidative defense and reduced advanced glycation end-product formation by metabolic adaptation in non-small-cell-lung-cancer patients

Fig. 2: Oxidative and abundance changes of glucose and methylglyoxal metabolic enzymes in lung cancer patients.The alternative text for this image may have been generated using AI.

Glycolytic enzymes were not only more abundant (marked with thick margin and bold writing) but also often more oxidized (red colored) in lung tumors. Oxidation might interfere with enzyme’s functionality. Main methylglyoxal (MG) detoxifying enzymes glyoxalase 1 (GLO1) and glyoxalase 2 (GLO2) seem to be less active (GLO1) and less abundant in tumor (GLO2). Furthermore, almost all enzymes of the citrate cycle were upregulated in tumor. Significance threshold for both oxidation and abundance: p value < 0.05 (unpaired two-sided Student’s t test). 1,3BPG 1,3-bisphosphoglycerate, 2PG 2-phosphoglycerate, 3PG 3-phosphoglycerate, 3PHP 3-phosphohydroxypyruvate, 6PG 6-phosphogluconate, 6PGD 6-phosphogluconate dehydrogenase, 6PGL 6-phosphogluconolactone, ACO2 aconitase, ALDOA/B aldolase A/B, ACLY citrate synthase, αKG α-ketoglutarate, DHAP dihydroxyacetone phosphate, E4P/F6P erythrose 4-phosphate or fructose-6-phosphate, ENO1 enolase 1, F1,6BP fructose 1,6-bisphosphate, FH fumarase, G3P glycerol-3-phosphate, G3P/S7P G3P or sedoheptulose 7-phosphate, G6P glucose-6-phosphate, GAPDH glyceraldehyde-3-phosphate dehydrogenase, GPD glycerol-3-phosphate dehydrogenase, G6PD glucose-6-phosphate dehydrogenase, GPI glucose-6-phosphate isomerase, GR glutathione reductase, GSH glutathione, GSS glutathione synthetase, GSSG glutathione disulfide, HK2 hexokinase 2, IDH1/2 isocitrate dehydrogenase 1/2, LDHA lactate dehydrogenase A, LDHD probable D-lactate dehydrogenase, MDH2 malate dehydrogenase 2, OGDH oxoglutarate (α-ketoglutarate) dehydrogenase, OxaloAc oxaloacetate, PC pyruvate carboxylase, PDH pyruvate dehydrogenase, PEP phosphoenolpyruvate, PFK phosphofructokinase, PGAM1 phosphoglycerate mutase 1, PGK1 phosphoglycerate kinase 1, PGLS 6-phosphogluconolactonase, PHGDH phosphoglycerate dehydrogenase, PKM2 pyruvate kinase M2, R5P/X5P ribose or xylulose 5-phosphate, RPE ribulose-phosphate-3-epimerase, RPI ribose 5-phosphate isomerase, SDHA succinate dehydrogenase, sLG S-lactoylglutathione, Succ-CoA succinyl CoA, SUCLG2 succinate-CoA ligase, TALDO transaldolase, TKT transketolase, TPI triosephosphate isomerase.

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