Fig. 4: Illustration of radiotherapy planning: uniform distance margin (Standard Plan) vs GliODIL vs. PDE solution. | Nature Communications

Fig. 4: Illustration of radiotherapy planning: uniform distance margin (Standard Plan) vs GliODIL vs. PDE solution.

From: Individualizing glioma radiotherapy planning by optimization of a data and physics-informed discrete loss

Fig. 4: Illustration of radiotherapy planning: uniform distance margin (Standard Plan) vs GliODIL vs. PDE solution.

a Model inputs including the FET-PET metabolic map and tumor segmentation data. b Illustration of the distance from the tumor core segmentation and its 1.5 cm isoline, adjusted for brain boundaries. This serves to define the Standard Plan and compare tumor cell distributions for both GliODIL and PDEGliODIL, ensuring equal total 3D volumes across plans. Also shown is the absolute difference in distribution between GliODIL and PDEGliODIL, exceeding 20%. c Visualization of radiotherapy plans including the Standard Plan, GliODIL, and PDEGliODIL.

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