Fig. 2: Both Eomes depletion and Brg1 inhibition (“BRGi”) result in loss of accessibility at distal regulatory regions. | Nature Communications

Fig. 2: Both Eomes depletion and Brg1 inhibition (“BRGi”) result in loss of accessibility at distal regulatory regions.

From: Eomesodermin in conjunction with the BAF complex promotes expansion and invasion of the trophectoderm lineage

Fig. 2

a Heatmaps of differentially-accessible sites at 12, 24, and 48 h after Eomes depletion. b Distance distribution of sites showing reduced accessibility 12 h after Eomes depletion from nearest TSS. c Selected GO terms of genes nearest differentially-accessible sites 12 h after Eomes depletion. White bars correspond to TE-related terms, grey bars correspond to cell interactions and motility-related terms. d Enriched consensus motifs at sites of reduced accessibility 12 h after Eomes depletion. Shown are HOMER binomial P values. e Heatmaps of differentially-accessible sites at 1, 12, 24, and 48 h after BRGi. f Distribution of distances from nearest TSS of sites with reduced accessibility 12 h after BRGi. g Selected enriched consensus motifs at sites of reduced accessibility after 12 h of BRGi. Shown are HOMER binomial P values. h Schematic of overlap between differentially accessible sites at 12, 24, and 48 h timepoints between Eomes-depleted and Brg1-inhibited TSCs.

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