Fig. 5: Trophectoderm of Eomes null embryos does not implant and migrate through the uterine epithelium.

Confocal imaging of representative sections of a control Eomes-expressing and b Eomes-null embryos at 5.5 dpc within the decidua carrying the ubiquitiously expressed transgene mTomato, stained for Eomes and mTomato, counterstained with DAPI. 18 control (Eomes positive) and 4 Eomes-null embryos in the decidua were analysed for this study. Lower panel is a higher magnification image of the embryos in the upper panel. Scale bar = 100 μm. Arrow indicates invaded P-TGC. Arrowhead shows intact uterine epithelium.