Table 2 Data collection and refinement statistics for X-ray crystal structures

Space group

C222₁

C222₁

 a, b, c (Å)

39.35, 179.53, 140.12

39.46, 178.85, 139.70

 α, β, γ (°)

90.0, 90.0, 90.0

90.0, 90.0, 90.0

 Resolution (Å)

44.88- 1.75 (1.84-1.75)^a

44.71-1.72 (1.78-1.72)^a

 R_pim

0.076 (1.04)^a

0.060 (1.31)^a

 I/σ(I)

11.1 (1.4)^a

14.0 (1.4)^a

 CC1/2

0.994 (0.540)^a

0.987 (0.480)^a

 spherical

86.4 (27.8)^a

88.7 (25.3)^a

 ellipsoidal

90.0 (38.5)^a

90.7 (29.9)^a

 Redundancy

29.2 (32.3)^a

30.1 (32.1)^a

 Resolution (Å)

44.9-1.75

44.7-1.72

 R_work/R_free

20.86/22.64

20.47/22.44

 Protein

3084

3077

 Ligand

34

32

 Other

447

485

 Protein

30.04

30.76

 Ligand

17.29

17.49

 Other

43.85

46.46

 Bond lengths (Å)

0.008

0.008

 Bond angles (°)

0.800

0.820