Fig. 4: Persistent SN-ROP activation patterns correlate with long-term CAR-T cell persistence. | Nature Communications

Fig. 4: Persistent SN-ROP activation patterns correlate with long-term CAR-T cell persistence.

From: Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells

Fig. 4

a Upper: Percentages of active-type T cell clusters as a function of time in individual patients. Lower: Percentages of biotin+ cells at 90 days post-infusion in each patient. b Correlations of the percentages of indicated cell clusters with CAR-T cell persistence at day 90 post-infusion. Each dot represents an individual CAR-T patient. The solid line represents the fitted linear regression. Pearson correlation coefficients (R2) and exact two-sided P values are shown in the plots. Results for additional clusters are provided in Supplementary Fig. 11. c Contour plots of PDI versus ERO1B expression at day 28 post-infusion (left) and CAR-T cells versus all T cells (right) in samples from patients 1908 and 1903 at day 90 post-infusion.

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