Fig. 2: Reaction design and development.

a Reaction development. b Isolated vinyl p-QM intermediate and its reactivities. c Computed Es(r) of vinyl p-QM intermediate with Zn(OTf)2 at the 0.004 a.u. isodensity surface. d Local softness analysis.

a Reaction development. b Isolated vinyl p-QM intermediate and its reactivities. c Computed Es(r) of vinyl p-QM intermediate with Zn(OTf)2 at the 0.004 a.u. isodensity surface. d Local softness analysis.