Fig. 5: Ye proteomic analysis.
From: In-host evolution of Yersinia enterocolitica during a chronic human infection
a Gene set enrichment analysis (GSEA) of biological process gene ontology terms across pairwise comparisons of Ye proteomes. Positive normalized enrichment scores (NES) calculated by GSEA algorithm are shown in red and correspond to enriched terms in the first isolate in the comparison, while negative NES are shown in blue and correspond to enriched term in the second isolate in the comparison. The nominal p-value is calculated according to GSEA algorithm. Multiple testing is adjusted by the Benjamini-Hochberg procedure (p.adjust). b Heatmap for all pairwise comparisons of protein differential abundance between the 4 clinical isolates, with the corresponding genes displayed on the right. Proteins are grouped in categories with different colors based on Y11 RefSeq and Uniprot annotations, and bibliography. Log2(foldchange) shown in red corresponds to a protein more abundant in the first isolate in the comparison, while log2(foldchange) shown in blue corresponds to a protein more abundant in the second isolate in the comparison. In each category, proteins are ordered by Y11 locus order. Source data are provided as a Source Data file.
