Table 1 Mean ( ± SD) values of baseline sample demographic and clinical variables of the combined Michigan and Groningen group, individual center values, and statistical comparisons between the two groups

From: A multicenter longitudinal study of cholinergic subgroups in Parkinson disease

Variable

Combined

(N = 245)

Michigan

(N = 149)

Groningen

(N = 96)

Statistic

P

Sex

male/female

(Male % total)

178/67

(72.6%)

113/36

(75.8%)

65/31

(67.7%)

χ2 = 1.555

0.2124

Age (years)

66.8 ± 8

67.21 ± 7.57

66.24 ± 8.61

t = 0.907

0.3658

MoCA

score

25.7 ± 3.2

26.2 ± 3.26

25 ± 3.04

t = 2.919

0.0039*

MDS-UPDRSII

total score

8.3 ± 5.7

7.32 ± 6.08

9.88 ± 4.69

t = −3.686

<0.001*

MDS-UPDRSIII

total score

35 ± 13.6

37.58 ± 13.98

30.98 ± 11.99

t = 3.919

<0.001*

MDS-UPDRS

PIGD subscore

0.2 ± 0.1

0.18 ± 0.16

0.13 ± 0.1

t = 2.974

0.0032*

Hoehn & Yahr

2.2 ± 0.7

2.46 ± 0.6

1.8 ± 0.61

t = 8.251

<0.001*

Motor disease duration

(years)

4.4 ± 4.3

6.04 ± 4.73

1.73 ± 1.11

t = 10.616

<0.001*

LED (mg)

 

603.47 ± 413.1

   
  1. Gender distribution is presented as proportions. Unequal variance independent samples t tests were applied to test group differences in numerical variables while chi-square contingency tests were used for categorical variables. Statistically significant site comparisons at uncorrected two-tailed α = 0.05 are marked with an asterisk.
  2. *Group differences between the Michigan and Groningen cohorts.
  3. MoCA Montreal Cognitive Assessment, MDS-UPDRS Movement Disorder Society Revised Unified Parkinson’s Disease Rating Scale, PIGD postural instability and gait difficulty, LED levodopa equivalent dose.
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